Treatment Failure
563 PACT Study is investigating to see if taking prazosin can help reduce nightmares and other sleep problems in people who have PTSD
Raskind, E
McFall
(Funded by the Department
BACKGROUND: In randomized trials, prazosin, an α1 -adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder
Prazosin was well toler-ated, and
Our primary aim was to measure the effects of prazosin on drinking [primary measure: DPW], and to
Trial of Prazosin for Post‐Traumatic Stress Disorder in Military Veterans | Semantic Scholar
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However, updated 2017 guidelines from the Veterans Affairs/Department of Defense (VA/DoD) 5 and data from the 2018 Prazosin and Combat Trauma PTSD (PACT) trial 6 contradict these original Peterson K, Williams T, et al
The trial was a major scientific success and constitutes one of the largest autism intervention studies completed the Prazosin and Combat Trauma PTSD (PACT) trial to determine the efficacy of prazosin in The PACT trial was a 26-week, multicenter, double-blind, randomized, controlled trial that My Research and Language Selection Sign into My Research Create My Research Account English; Help and support
AD PMID 29414272
A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and
Consequently, I read with great interest the results from the The PACT Trial
Consequently, I read with great interest the results from the PACT trial published in this week’s NEJM
Citation 63, Citation 67 It is noteworthy that incidence of new or worsening suicidal ideation in the PACT trial was less common in the prazosin group than in the placebo group
Trial criteria may exclude significant sub-groups, and therefore a 2018 study may not provide the final evidence of prazosin