Diltiazem is used to treat high blood pressure and to control angina (chest pain)
Important warnings Liver problems warning: This
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties
When possible, use a non-CYP3A4-metabolized statin together with diltiazem; otherwise, dose adjustments for both diltiazem and the statin should be
Drug interaction studies involving statins and digoxin support a role for P-gp
Diltiazem is metabolized by the cytochrome P450 system and is an inhibitor of CYP 3A4 activity, which can lead to serious drug-drug interactions and potentiation of the hepatotoxic effects of other medications
1 While mild acute pancreatitis carries a mortality of <1%, mortality rates for severe pancreatitis can reach as high as 30%
Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statins
Clinically important drugs that interact with statins and increase the risk of adverse effects include fibrates, diltiazem, verapamil, and amiodarone
inflammation of the liver or pancreas
Each statin has different concerns regarding drug-drug and drug-food interactions because of the specific pathways through which each is metabolized Similarly to amiodarone, amlodipine, diltiazem, and verapamil inhibit CYP3A4
Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class
This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle Calcium channel blockers, like amlodipine, diltiazem, verapamil, and nifedipine
Atorvastatin oral tablet dosage and frequency will depend upon several factors, the most important being the medical condition it is being targeted for and Immediate-release diltiazem tablets are usually taken three or four times a day
Diltiazem is well absorbed from the gastrointestinal tract and is subject to an extensive first-pass effect, giving an absolute bioavailability (compared to intravenous administration) of about 40%
Statins
Grapefruit juice can increase levels of drugs metabolized by CYP3A4
Many in vitro studies have investigated the drug–drug interactions of statins and CCBs